2-AZETIDINEMETHANEAMINES AND 2-PYRROLIDINEMETHANEAMINES AS TAAR-LIGANDS,申请号US20080176456-传众专利搜索

2-AZETIDINEMETHANEAMINES AND 2-PYRROLIDINEMETHANEAMINES AS TAAR-LIGANDS

申请公布号：US2009029962(A1)

申请号：US20080176456

申请日期：2008.07.21

申请公布日期：2009.01.29

申请人：

GALLEY GUIDO;GOERGLER ANNICK;GROEBKE ZBINDEN KATRIN;NORCROSS ROGER;STALDER HENRI

发明人：GALLEY GUIDO;GOERGLER ANNICK;GROEBKE ZBINDEN KATRIN;NORCROSS ROGER;STALDER HENRI

分类号：A61K31/397;A61K31/40;C07D205/04;C07D207/09

主分类号：A61K31/397

摘要：The present invention relates to compounds of formula I wherein R1, R2, R3, Ar, n and o are as defined herein and to their pharmaceutically acceptable active salts. Compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1 and are useful for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.