1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT

申请公布号：CA2722177(C)

申请号：CA20092722177

申请日期：2009.04.22

申请公布日期：2016.08.16

申请人：

GILEAD SCIENCES, INC.

发明人：BUTLER, THOMAS;CHO, AESOP;KIM, CHOUNG U.;SAUNDERS, OLIVER L.;ZHANG, LIJUN;PARRISH, JAY

分类号：C07D487/04;A61K31/395;A61K31/41;A61K31/4188;A61K31/7052;A61P31/12;C07H19/23

主分类号：C07D487/04

摘要：Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides of Formula (I), nucleoside phosphates and prodrugs thereof, wherein the l' position of the nucleoside sugar is substituted, and wherein each of X1 or X2 is independently C-R10 or N. The compounds, compositions, and methods provided may be useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. (see formula I)

MEDICAL DEVICE

ULTRASONIC DIAGNOSTIC SYSTEM AND PORTABLE ULTRASONIC DIAGNOSTIC APPARATUS THEREOF

FRACTURE FRAGMENT MOBILITY TESTING FOR VERTEBRAL BODY PROCEDURES

REPRESENTATION OF LARGE, VARIABLE SIZE DATA SETS ON SMALL DISPLAYS

PROCESS FOR THE PRODUCTION OF 2-[4-(3- AND 2-FLUOROBENZYLOXY) BENZYLAMINO] PROPANAMIDES

NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR

POLYIMIDE PRECURSOR COMPOSITION, METHOD FOR PREPARING POLYIMIDE, POLYIMIDE PREPARED BY USING THE METHOD, AND FILM INCLUDING THE POLYIMIDE

Polymeric Compositions and Polymerization Initiators Using Photo-Peroxidation Process

METHOD FOR PRODUCING FLUORINE-CONTAINING POLYMER

POLYVINYL ALCOHOL RESIN COMPOSITION AND MOLDED ARTICLE THEREOF

METHOD FOR PRODUCING A HYDROGENATED BLOCK COPOLYMER, HYDROGENATED BLOCK COPOLYMER OBTAINED BY SAID PRODUCTION METHOD AND COMPOSITION THEREOF

HYDROPHILIC ALIPHATIC POLYURETHANE FOAMS

Compositions Containing Aromatic Aldehydes and Their Use in Treatments

DIOXANES DERIVED FROM REGROUPING CARBOHYDRATES AND C-GLYCOSIDES, PROCESS FOR OBTAINING SAME AND USES THEREOF

GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR siRNA

BENZIMIDAZOLE DERIVATIVES

N-BIARYLAMIDES

TREATMENT OF ENDOMETRIOSIS

Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors

SUBSTITUTED AMINOPROPENYL PIPERIDINE OR MORPHOLINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE