OPHTHALMIC NANOPARTICULATE FORMULATION OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR

申请公布号：WO2006062875(A1)

申请号：WO2005US43858

申请日期：2005.12.05

申请公布日期：2006.06.15

申请人：

MERCK & CO., INC.;PANMAI, SANTIPHARP;ALANI, LAMAN, L.

发明人：PANMAI, SANTIPHARP;ALANI, LAMAN, L.

分类号：A61K31/415

主分类号：A61K31/415

摘要：<p>The present invention is directed to a novel pharmaceutical composition suitable for ophthalmic use comprising nanoparticles dispersed in a liquid dispersion medium, wherein said nanoparticles comprise a cyclooxygenase-2 selective inhibitor having adsorbed on the surface thereof at least one surface stabilizer. The ophthalmic formulation of the present invention is stable, non-irritating and sufficiently bioavailable. The invention also encompasses a process for making as well as a kit for preparing the novel ophthalmic formulation.</p>

LINEAR MOTOR

Production of a solder used in the production of electronic and/or optoelectronic components comprises applying layers containing gold and tin to a wetting metal and heating so that the gold and tin layers react to form an alloy

Radiation detector e.g. flat image detector, for e.g. X-ray radiography, has lens array with micro lenses arranged between scintillator plate and photo sensor, where lenses are partially designed as convex lenses

Multi port semiconductor memory device, has test mode control device executing core test by converting serial data communication into parallel data communication during selected core test mode, where control device has mode adjusting unit

Living organism e.g. patient, biodata e.g. disease history, reference value determining device, has sensor provided for non-invasive measurement of two signals selected from group such as continuous wave fluctuation, spot oxygen saturation

Biosignal recording device for use in data recording system, has mobile controller connected with sensor e.g. pulsoxymetric sensor, where sensor and controller are connected with wearing strap for mobile application

Vehicle transmission control, with a lock clutch, sets the clutch disengagement after a fuel feed interruption based on the motor coolant temperature

Vehicle drum-in-hat disc brake assembly for controlling the movement of e.g. a vehicle rotor uses bolts to secure an abutment tower to a caliper-bracket assembly and to secure the caliper-bracket assembly and a shield to an axle flange

METHOD FOR TREATING FIBROMYALGIA AND RELATED CONDITIONS

VESSEL FILL LEVEL INDICATING DEVICE

Cable window lift rail for opening and closing door of motor vehicle, has end piece provided with cable outlet for selective execution of cable, which is arranged in pre-determined angle to another outlet and tangential to guide roller

Anti-roll bar fastening device for motor vehicle, has bearing unit surrounding section of anti-roll bar, and clamp-shaped component for retaining bearing unit and section of bar, where fastening units fasten clamp-shaped component

Hinged swiveling device for rotational mounting of an element with a surface has a linking device for mounting the element and a retaining device

Single chip semiconductor-opto component e.g. optothyristor, for e.g. controlling infrared lighting system, has optodiode exhibiting relative spectral sensitivity, which is adapted to relative spectral sensitivity of eye

Method for setting up and removing plaster dressing to or from body part, involves fitting bearing for cutter on body part to slit plaster dressing, and bearing extends along desired cutting line

Bedding cover e.g. bedtick, for covering e.g. human, has ceramic material provided on side of textile material as coating, where ceramic material covers textile material in coated range of specific percentage

Water bed mattress or water cushion has foil, where mattress or cushion is filled with liquid, and spherical pieces of gel are added to liquid, which float in liquid freely

Use of a composition comprising kappa opioid receptor antagonist e.g. for producing a drug for the treatment of dissociative disorders in humans

Horizontal wood splitter for heavy wood has support table with fixed section and vertically movable section with movable side sections, limit switches and, for safety, a stop switch which operates the processor control unit

Gear`s transmission ratio determining method, involves determining difference of positions of engine during positioning of forcipate units in two known relative positions, and changing positions of engine in defined intervals