PROCESS FOR PRODUCING NEW OXIME DERIVATIVES OF 3-THIADIAZOLYTHIO-METHYL-7-AMINOTHIAZOLYLACETAMIDO-CEPH-3-EME-4-CARBOXYLIC ACIDS,申请号HU1978RO00963-传众专利搜索

PROCESS FOR PRODUCING NEW OXIME DERIVATIVES OF 3-THIADIAZOLYTHIO-METHYL-7-AMINOTHIAZOLYLACETAMIDO-CEPH-3-EME-4-CARBOXYLIC ACIDS

申请公布号：HU181961(B)

申请号：HU1978RO00963

申请日期：1978.02.17

申请公布日期：1983.11.28

申请人：

ROUSSEL UCLAF SA,FR

发明人：HEYMES,RENE,FR;LUTZ,ANDRE,FR

分类号：C07D501/06;A61K;A61K31/545;A61K31/546;A61P31/04;C07D;C07D285/08;C07D499/12;C07D501/00;C07D501/18;C07D501/36;C07D501/60;(IPC1-7):07D501/36

主分类号：C07D501/06

摘要：<p>The compounds correspond to the formula: <IMAGE> in which R1 represents hydrogen or certain protective groups, R2 represents certain alkyl radicals, R3 represents C1-C4 alkyl or alkoxy radicals and A represents hydrogen, an alkali metal, alkaline-earth metal, magnesium or amine cation or an ester group; the preferred compounds have the syn configuration. The preparation is carried out by creating the amide bond from the carboxyl component and the substituted 7-aminocephem component, followed by an acid hydrolysis, a hydrogenolysis or a treatment with thiourea when it is desired to remove the protective groups R1 and A. The compounds are active with respect to gram (+) and (-) bacteri; they can be used in the treatment of relevant infections.</p>