Substituted triazole boronic acid compounds,申请号US201314646782-传众专利搜索

Substituted triazole boronic acid compounds

申请公布号：US9464098(B2)

申请号：US201314646782

申请日期：2013.11.29

申请公布日期：2016.10.11

申请人：

HOFFMANN-LA ROCHE INC.

发明人：Lynch Stephen M.;Neidhart Werner;Plancher Jean-Marc;Schulz-Gasch Tanja

分类号：A61K31/4192;C07F5/02

主分类号：A61K31/4192

地址：Nutley NJ US

摘要：The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease.;

主权项：1. A compound of formula (I): wherein: R1, R1′ and R1″, of each other, are hydrogen, alkoxy, halogen or —CF3; and R2 is C1-7 alkyl or phenyl, or a pharmaceutically acceptable salt thereof.