4-AMINOPYRIDINES AND A PHARMACEUTICAL COMPOSITION,申请号RU19950122612-传众专利搜索

4-AMINOPYRIDINES AND A PHARMACEUTICAL COMPOSITION

申请公布号：RU2126388(C1)

申请号：RU19950122612

申请日期：1994.03.02

申请公布日期：1999.02.20

申请人：

BERINGER MANNKHAJM GMBKH

发明人：VOL'FGANG FON DER ZAAL';RAJNKHARD KHEK;KHERBERT LAJNERT;TOMAS POLL;KARLKHAJNTS SHTEGMAJER;KHEL'MUT MIKHEL'

分类号：A61K31/135;A61K31/44;A61K31/4409;A61K31/4425;A61K31/4427;A61P7/02;A61P9/10;A61P35/00;C07D213/74;C07D401/12;C07D409/12;C07D417/12;(IPC1-7):C07D213/74

主分类号：A61K31/135

摘要：FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new 4-aminopyridines of the general formula (I): <EMI ID=0.389 HE=36 WI=66 TI=CHI> where R means groups R<SP>6</SP>-SO<SB>2</SB>-NR<SP>7</SP>-, R<SP>6</SP>-NR<SP>7</SP>-SO<SB>2</SB>-, R<SP>6</SP>-SO<SB>2</SB>-O-, R<SP>6</SP>-O-SO<SB>2</SB>-; R means hydrogen or halogen atom, cyano-, alkyl-, alkoxyl- or halogenalkyl-group; X means oxygen or sulfur atom or NH-group; R and R are similar or distinct and mean hydrogen atoms or alkyl-groups; R means hydrogen atom, alkyl- or aralkyl-group; R means alkyl-, cycloalkyl-, aryl-, heteroaryl-, aralkyl- or heteroarylalkyl-group; aryl- or heteroaryl-groups can be substituted mono- or multiplied with nitro-group, halogen, hydroxyl, amino-group, carboxyl, halogenalkyl, alkoxycarbonyl, aralkoxycarbonyl, alkyl, cycloalkyl, alkoxyl, alkylamino-group or one or some groups -Y--CO<SB>2</SB>R , -O-Y--CO<SB>2</SB>R ; alkyl groups can be mono- or multiplied substituted with halogen; R means hydrogen, alkyl, cycloalkyl or alkenyl residues and these residues can be mono- or multiplied substituted with halogen, hydroxyl, alkoxyl, amino-group or alkylcarbonyl, or means cyanoalkyl, heteroaryl, aryl or aralkyl residues; aryl or heteroaryl residues can be mono- or multiplies substituted with carboxy-group, or means residue -Y--CO<SB>2</SB>R or -Y--CONR<SP>8</SP>R ; Y means linear or branched alkylene chain; R and R are similar or distinct and mean hydrogen or alkyl-groups that can be mono- or multiplied substituted with hydroxyl, alkoxyl, amino-group or carboxyl, or R and R together with N-atom with which they are bound form saturated ring that can has additionally oxygen, sulfur or nitrogen atom, and their physiologically acceptable salts also. 4-Aminopyridine of the formula (I) according p. 1 where R means groups R<SP>6</SP>-SO<SB>2</SB>-O-, R<SP>6</SP>-O-SO<SB>2</SB>-; R<SP>6</SP>-NR<SP>7</SP>-SO<SB>2</SB>-; R means hydrogen or halogen atom, alkyl, alkoxyl or trifluoromethyl-group; X means oxygen atom or NH-grou