环状RNA circ‑ZKSCAN1的用途
申请公布号:CN105524924B
申请号:CN201511025996.2
申请日期:2015.12.29
申请公布日期:2017.03.22
发明人:罗景燕;刘波;姚志成;李伟琴;赖炳权
分类号:C12N15/113(2010.01)I;A61K31/713(2006.01)I;A61P35/00(2006.01)I;C12Q1/68(2006.01)I
主分类号:C12N15/113(2010.01)I
代理人:郝传鑫;宋静娜
地址:510000 广东省广州市国际生物岛螺旋三路8号标产三期2栋602单元
摘要:本发明提供了一种环状RNA circ‑ZKSCAN1的用途,本发明首先证实了circ‑ZKSCAN1基因的客观存在;本发明通过检测肝癌病人中circ‑ZKSCAN1基因表达情况,发现其表达水平明显降低;本发明将转染了circ‑ZKSCAN1基因shRNA序列的肝癌细胞与转染空载体的对照肝癌细胞相比,发现其增殖速度、细胞迁移率及细胞侵袭能力等均显著升高。circ‑ZKSCAN1基因及其表达产物作为诊断肝癌的标志物,使肝癌诊断更加准确、快速,作为制备治疗肝癌药物的靶基因为治疗肝癌提供了新的治疗靶点和治疗途径。
主权项:环状RNA circ‑ZKSCAN1在制备肝癌诊断试剂盒中的用途,其特征在于,所述环状RNA circ‑ZKSCAN1的CircBase ID为hsa_circ_0001727,所述环状RNAcirc‑ZKSCAN1的核苷酸序列如SEQ ID NO:14所示,所述环状RNAcirc‑ZKSCAN1的结构是由如SEQ ID NO:14所示的核苷酸序列首尾连接成的环状结构。
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