COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASES AND LUNG INJURY,申请号WO2016US41776-传众专利搜索

COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASES AND LUNG INJURY

申请公布号：WO2017008076(A1)

申请号：WO2016US41776

申请日期：2016.07.11

申请公布日期：2017.01.12

申请人：

INSMED INCORPORATED

发明人：CHEN, Kuan-Ju;LEIFER, Franziska;MALININ, Vladimir;PERKINS, Walter;ZHANG, Jimin;DIPETRILLO, Keith

分类号：C07H21/04;A61K9/127;A61K48/00;C12N15/88

主分类号：C07H21/04

摘要：Compositions comprising an RNA interference (RNAi) compound complexed to or encapsulated by lipid particles are provided. The lipid particle is a lipid nanoparticle, a liposome or a combination thereof. The lipid particle comprises a cationic lipid, a phospholipid, a sterol or a tocopherol or a derivative thereof, and a conjugated lipid. The invention also provides methods for treating pulmonary diseases or disorders such as pulmonary fibrosis and sarcoidosis using the compositions comprising the RNAi-lipid particles of the invention. The methods comprise administering one or more of the RNAi compositions to the lungs of the patient in need thereof via an inhalation delivery device, for example, a nebulizer, dry powder inhaler, or a metered dose inhaler.