水貂绿脓杆菌血清B型菌株及其灭活疫苗和应用
申请公布号:CN105543127A
申请号:CN201510991185.1
申请日期:2015.12.26
申请公布日期:2016.05.04
发明人:杨朋欣;丁国杰;关俊威;刘可姝;张凤强;李洪艳;闫冰;李敏;陈欣
分类号:C12N1/20(2006.01)I;A61K39/104(2006.01)I;A61P31/04(2006.01)I;A61P11/00(2006.01)I;A61P7/04(2006.01)I;C12R1/385(2006.01)N
主分类号:C12N1/20(2006.01)I
代理人:余光军
地址:150069 黑龙江省哈尔滨市香坊区哈平路277号
摘要:本发明公开了一株水貂绿脓杆菌血清B型菌株及由其制备的灭活疫苗和应用,属于水貂绿脓杆菌菌株的分离和应用领域。本发明从多例疑似患有水貂出血性肺炎的病死水貂肺脏,通过分离、鉴定和筛选等方法,最终得到一株致病力好、稳定性高的水貂绿脓杆菌血清B型SD004菌株,其微生物保藏编号为:CGMCC No.11761。本发明还公开了用该菌株制备灭活疫苗的方法,包括:培养菌株,获得菌液;加入灭活剂,将菌液灭活;混匀佐剂和菌液,配苗,即得。安全性、免疫保护试验证明,用本发明所分离的水貂绿脓杆菌血清B型SD004菌株制备的灭活疫苗具有较高的安全性和良好的免疫原性,对于绿脓杆菌所致的水貂出血性肺炎能够提供好的临床保护。
主权项:一株水貂绿脓杆菌(Pseudomonas aeruginosa)血清B型菌株,其特征在于,其微生物保藏编号为:CGMCC No.11761。
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