PHARMACEUTICAL COMPOSITION FOR INHIBITING AUTOPHAGY OF MOTOR NEURONS AND USE THEREOF,申请号EP20120883034-传众专利搜索

PHARMACEUTICAL COMPOSITION FOR INHIBITING AUTOPHAGY OF MOTOR NEURONS AND USE THEREOF

申请公布号：EP2992879(A1)

申请号：EP20120883034

申请日期：2012.08.17

申请公布日期：2016.03.09

申请人：

CHINA MEDICAL UNIVERSITY

发明人：LIN, SHINN-ZONG;HARN, HORNG-JYH;CHIOU, TZYY-WEN;HSUEH, KUO-WEI

分类号：A61K31/192;A61K31/198;A61K31/365;A61K31/7024;A61K31/7048;A61P21/04;A61P25/00;A61P25/14

主分类号：A61K31/192

摘要：A pharmaceutical composition for inhibiting the autophagy of motor neurons comprising an effective amount of an active ingredient selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable ester of the compound and combinations thereof: wherein A is a C1-C5 alkyl optionally having one or more unsaturated bonds and optionally being substituted by one or more substituents selected from a group consisting of -OH, =O and C1-C3 alkyl; X is H, -OH, Y is O or S and can optionally combine with A to form a five-membered ring; and R 1 is H or a substituted or unsubstituted C1-C20 alkyl, wherein one or more -CH 2 - of the C1-C20 alkyl are optionally being replaced by -NH- or -O-.