活疫苗耐热保护剂及其制备方法和应用
申请公布号:CN105288640A
申请号:CN201510835120.8
申请日期:2015.11.25
申请公布日期:2016.02.03
发明人:孙德君;崔艳丽;闫冰;李洪艳;刘鑫莹;张影;丁国杰;张凤强;周靓靓
分类号:A61K47/42(2006.01)I;A61K47/26(2006.01)I;A61K47/32(2006.01)I;A61K47/20(2006.01)I;A61K39/215(2006.01)I;A61P31/14(2006.01)I
主分类号:A61K47/42(2006.01)I
代理人:余光军;李霞
地址:150069 黑龙江省哈尔滨市香坊区哈平路277号
摘要:本发明公开了一种活疫苗耐热保护剂及其制备方法和应用,属于活疫苗耐热保护剂的制备及应用领域。本发明活疫苗耐热保护剂的组分包括:海藻糖、葡萄糖、明胶、硫脲和聚乙烯吡咯烷酮K30。应用本发明耐热保护剂制备的鸡传染性支气管炎活疫苗冻干时间短,耗费成本低;37℃耐热检验后,疫苗滴度下降少,疫苗的效力保持稳定。本发明进一步对该耐热保护剂制备鸡传染性支气管炎活疫苗的冷冻干燥方式进行优化,使冻干时间由48小时缩短至24小时且耐热后疫苗滴度下降少,疫苗2-8℃保存期达36个月,疫苗的效力更加稳定,安全性好。
主权项:一种活疫苗耐热保护剂,其特征在于,包括以下各组分:海藻糖、葡萄糖、明胶、硫脲、聚乙烯吡咯烷酮K30和纯水。
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