QUINOXALINE-CONTAINING COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS

申请公布号：MY155851(A)

申请号：MY2010PI02236

申请日期：2008.11.14

申请公布日期：2015.12.15

申请人：

ENANTA PHARMACEUTICALS, INC.

发明人：GAI, YONGHUA;OR, YAT SUN;WANG, ZHE

分类号：A01N43/60

主分类号：A01N43/60

摘要：THE PRESENT INVENTION DISCLOSES COMPOUNDS OF FORMULA I AND II OR PHARMACEUTICALLY ACCEPTABLE SALTS, ESTERS, OR PRODRUGS THEREOF: WHICH INHIBIT SERINE PROTEASE ACTIVITY, PARTICULARLY THE ACTIVITY OF HEPATITIS C VIRUS (HCV) NS3-NS4A PROTEASE. CONSEQUENTLY, THE COMPOUNDS OF THE PRESENT INVENTION INTERFERE WITH THE LIFE CYCLE OF THE HEPATITIS C VIRUS AND ARE ALSO USEFUL AS ANTIVIRAL AGENTS. THE PRESENT INVENTION FURTHER RELATES TO PHARMACEUTICAL COMPOSITIONS COMPRISING THE AFOREMENTIONED COMPOUNDS FOR ADMINISTRATION TO A SUBJECT SUFFERING FROM HCV INFECTION. THE INVENTION ALSO RELATES TO METHODS OF TREATING AN HCV INFECTION IN A SUBJECT BY ADMINISTERING A PHARMACEUTICAL COMPOSITION COMPRISING THE COMPOUNDS OF THE PRESENT INVENTION.

(1H-BENZIMIDAZOL-2-YL)CARBAMATES

1,2-DIMETHYL-3 OR 5-PIPERAZINYL-PYRAZOLIUM SALTS

SURFACE-COATING COMPOSITIONS CONTAINING CALCIUM SALT LOSS-OF-DRY INHIBITORS AND A METHOD OF PREPARING SAME

HEATING ELEMENTS COMPRISING A PTC CERAMIC ARTICLE OF A HONEYCOMB STRUCTURE COMPOSED OF BARIUM TITANATE

CONJUNTO PARA ESTIRAMENTO DE FIBRAS DE VIDRO E PROCESSO PARA CONSERVACAO DE UM ANTECRISOL CONVENCIONAL EM UM ANTECRISOL COM UM CONJUNTO DE LUVA

PROCESSO PARA SEPARAR MAGNETICAMENTE CONTAMINANTES DESCOLORANTES DE BAIXA CAPACIDADE DE ATRACAO MAGNETICA DE UMA ARGILA CAOLINICA EM BRUTA

BOMBA PARA LAVADOR DE PARA-BRISAS

TERAPEUTICA HEMOSTATICA APERFEICOADA DA EPISTAXE E ELEMENTO PARA EXECUTA-LA

AUTOMATIC SWITCHING DEVICE

WERKWIJZE VOOR HET VERWIJDEREN VAN STIKSTOF- OXYDEN UIT AFGEWERKT GAS DOOR SELECTIEVE CONTACTREDUCTIE.

SLOTPEN.

PLAATSBEPALINGSINRICHTING.

ELECTROPHOTOGRAPHIC LIGHT SENSITIVE MATERIAL

COLOR PICTURE TUBE

CONTROL SYSTEM FOR MICRO PROCESSOR

MACHINE TOOL FOR FABRICATING HELICAL GEAR

FLOW CONTROL VALVE

MOUNTING RACK

BALL BEARING FOR LINEAR MOTION

STABILIZED POWER SOURCE