Antibody against human prostaglandin E<sub>2 </sub>receptor EP4,申请号US201113876763-传众专利搜索

Antibody against human prostaglandin E<sub>2 </sub>receptor EP4

申请公布号：US9175080(B2)

申请号：US201113876763

申请日期：2011.09.28

申请公布日期：2015.11.03

申请人：

NB HEALTH LABORATORY CO., LTD.

发明人：Takayama Kiyoshi;Shimizu Tomoko;Urushibata Yuji;Sugimoto Yukihiko

分类号：A61K39/395;C07K16/28;C07K17/00;G01N33/88

主分类号：A61K39/395

代理机构：

Westerman, Hattori, Daniels & Adrian, LLP

代理人：Westerman, Hattori, Daniels & Adrian, LLP

地址：Sapporo-Shi, Hokkaido JP

摘要：It is an object of the present invention to provide an antibody that binds to a human PGE2 receptor subtype EP4 and inhibits the function of EP4, or a functional fragment thereof. It is another object of the present invention to provide a medicament comprising the aforementioned antibody or a functional fragment thereof. Mice were immunized with the human PGE2 receptor subtype EP4, and a monoclonal antibody that suppresses the intracellular cAMP level increase induced by EP4 was screened. In addition, the CDR sequences of the obtained monoclonal antibody were determined.

主权项：1. A monoclonal antibody, wherein the antibody is produced from hybridomas with the international depositary accession Nos. FERM BP-11402 (NBG016-mAb14) and FERM BP-11403 (NBG016-mAb21).