PYRAZOLE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER AND AUTOIMMUNE DISORDERS,申请号WO2006GB02071-传众专利搜索

PYRAZOLE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER AND AUTOIMMUNE DISORDERS

申请公布号：WO2006134318(A1)

申请号：WO2006GB02071

申请日期：2006.06.06

申请公布日期：2006.12.21

申请人：

VERNALIS R & D LIMITED;WALMSLEY, DAVID, LEE;DRYSDALE, MARTIN, JAMES;NORTHFIELD, CHRISTOPHER, JOHN;FROMONT, CHRISTOPHE

发明人：WALMSLEY, DAVID, LEE;DRYSDALE, MARTIN, JAMES;NORTHFIELD, CHRISTOPHER, JOHN;FROMONT, CHRISTOPHE

分类号：C07D401/14;A61K31/4184;A61P35/00;A61P37/00;C07D403/04;C07D405/04;C07D451/04;C07D453/02;C07D487/04

主分类号：C07D401/14

摘要：Compounds of formula (I) are inhibitors of PDK1 and CHK1 activity, and of use in the treatment of cancer and autoimmune disorders (I) : wherein R2 is a radical of formula R7-(CH2)n-, or a radical of formula -Alk-N(-R8)-R9 wherein n is 0, 1 , 2 or 3 and AIk is C1-C6 alkylene; R7 is (i) a heterocyclic ring of 5 or 6 ring atoms coupled via a ring carbon wherein the sole heteroatom is nitrogen, optionally substituted by C1-C6 alkyl or aryl C1-C6 alkyl, (ii) 1-aza-bicyclo[2.2.2] oct-3-yl, or (iii) 8-methyl-8-aza-bicyclo[3.2.1] oct-3-yl; R8 and R9 are independently selected from hydrogen or C1-C3 alkyl; and the remaining substituents are as defined in the claims.