PULSATILE ONCE-A-DAY-DELIVERY SYSTEMS FOR MINOCYCLINE
申请公布号:CA2090561(A1)
申请号:CA19932090561
申请日期:1993.02.26
申请公布日期:1993.09.03
发明人:SHETH, NITIN V.;VALOROSE, JOSEPH J., JR.;ELLWAY, KEITH A.;GANESAN, MADURAI G.;MOONEY, KEIRAN G.;JOHNSON, JERRY B.
分类号:A61K9/00;A61K9/50;A61K9/52;A61K9/54;A61K9/56;A61K9/58;A61K31/65;A61P31/04;G02B6/42;H01L31/0232;H01L33/00;H01S5/00;(IPC1-7):A61K31/65
主分类号:A61K9/00
摘要:31,065-01 PULSATILE ONCE-A-DAY DELIVERY SYSTEMS FOR MINOCYCLINE Pharmaceutical delivery systems containing 7-dimethyl 6-deoxy 6-demethyltetracycline or a non-toxic acid addition salt thereof comprising mixtures of a minor proportion of slow-release blended polymer coated spherical granules adapted to release part of the minocycline in a medium having a pH of below 3.9 and the rest in the range of from about 4.0 to about 7.5 and a major proportion of coated or uncoated quick-release granules adapted to release minocycline in a medium having a pH of less than about 3.9 and oral dosage unit form capsules containing the above are provided. These systems and formulations provide enhanced therapeutic blood levels of minocycline for at least about 24 hours when administered to a subject only once-a-day, regardless of whether the patient is fed or fasted. Methods for the preparation of the systems and formulations are provided as well.
VERFAHREN ZUR HERSTELLUNG VON 3-JOD- UND 3- -BROMRIFAMYCIN S
INFORMATION WRITING SYSTEM OF MAGNETIC BUBBLE MEMORY UNIT
RECORD DISC REPRODUCING DEVICE
CHARACTER DISPLAY SYSTEM FOR JAPANESE INPUT DEVICE
DRIVING CIRCUIT FOR SWITCHING ELEMENT
CHARACTER DISPLAY SYSTEM FOR JAPANESE INPUT DEVICE
SHADING STRUCTURE FOR WRISTWATCH PROVIDED WITH LIGHTING DEVICE
LIQUID CRYSTAL INDICATOR DRIVING SYSTEM