ADENO-ASSOCIATED VIRUS SEROTYPE 5 VECTOR FOR TARGETED GENE DELIVERY,申请号KR20080032245-传众专利搜索

ADENO-ASSOCIATED VIRUS SEROTYPE 5 VECTOR FOR TARGETED GENE DELIVERY

申请公布号：KR100912270(B1)

申请号：KR20080032245

申请日期：2008.04.07

申请公布日期：2009.08.17

申请人：

UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, DANKOOKUNIVERSITY

发明人：LEE, HEUI RAN;CHOE, HAN SEOK;LEE, HAN SAEM;KIM, JEE YEON;SHIN, OH KYU;LEE, WON IL;JEONG, SUN JOO;PARK, KEE RANG

分类号：C12N15/66;C12N15/09;C12N15/86

主分类号：C12N15/66

摘要：An adeno-associated virus serotype 5 vector which is used as a targeted gene delivery is provided to target virus by inserting targeted motif peptide into capside protein of virus vector and improve gene delivery efficiency. A targeted recombinant virus vector is derived from an adeno-associated virus serotype 5 and comprises a nucleic acid sequence which encodes a capside protein in which targeted motif peptide is inserted. The targeted motif peptide has 5-25 amino acid. The targeted motif peptide recognizes a molecule which presents in tumor cell membrane. A molecule in the tumor cell membrane is sialyl Lewis X, integrin or tenascin C.