NOVEL SELECTIVE ANDROGEN RECEPTOR MODULATORS,申请号PH2015120155012-传众专利搜索

NOVEL SELECTIVE ANDROGEN RECEPTOR MODULATORS

申请公布号：PH12015501215(A1)

申请号：PH2015120155012

申请日期：2015.05.29

申请公布日期：2015.08.17

申请人：

PFIZER INC.

发明人：ANDERSON, JAMES, THOMAS;CHEKLER, EUGENE, LVOVICH, PIATNITSKI;ELLSWORTH, EDMUND, L;ERICKSON, BRUCE, KIPP;GILBERT, ADAM, MATTHEW;RICKETTS, ANTHONY, P;THOMPSON, DAVID, P;UNWALLA, RAYOMAND, JAL;VERHOEST, PATRICK, ROBERT

分类号：A61K31/4725;A61P3/00;A61P5/26;A61P5/28;A61P19/00;A61P21/00;A61P25/00;C07C255/58;C07D205/04;C07D207/08;C07D211/22;C07D217/26;C07D285/10;C07D401/04;C07D417/04

主分类号：A61K31/4725

摘要：The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or -CR0 --, where R0 is hydrogen, C1 -C6 linear or branched chain alkyl, etc., Z is -CRe --, or, -N--, where Re is hydrogen, C1 -C6 linear or branched chain alkyl,etc.; R1 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R2 are independently hydrogen or C1 -C6 linear or branched chain alkyl; R3 and R4 are independently hydrogen, C1 -C6 linear or branched chain alkyl, etc.;. R5 and R6 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.; R8 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R9 and R10 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.; Q is --CO--, --(CH2 )q --, --(CHRS )q --, or -(CRS Rt )q--, where RS and Rt are independently C1 -C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.