Complement split product C4d for the treatment of inflammatory conditions,申请号US201314412449-传众专利搜索

Complement split product C4d for the treatment of inflammatory conditions

申请公布号：US2015191520(A1)

申请号：US201314412449

申请日期：2013.07.02

申请公布日期：2015.07.09

申请人：

Medizinische Universität Wien

发明人：Hofer Johannes;Steinberger Peter;Zlabinger Gerhard;Böhmig Georg;Forster Florian;Leitner Judith;Wahrmann Markus;Merio Margarethe;Kovarik Johannes;Hölzl Markus;Isenman David E.

分类号：C07K14/47;G01N33/50

主分类号：C07K14/47

地址：Wien AT

摘要：The present invention relates to a pharmaceutical composition comprising complement split product C4d for use in treating an inflammatory condition, such as graft rejection, graft versus host disease, an autoimmune disease or atopy. The C4d to be used may be a multimer. Accordingly, also C4d multimers and their use in medicine, like the treatment of inflammatory conditions, is provided. Furthermore, the present invention provides a protein complex comprising C4d interacting with its ILT4 receptor. This protein complex may be used in screening methodsAlso antibodies specifically binding to the C4d multimer or the C4d/ILT4-protein complex are subject of the present invention.