Antisense oligonucleotides against neutral sphingomyelinase and neutral sphingomyelinase inhibitor GW4869 for degenerative neurological disorders

申请公布号：US9006205(B2)

申请号：US201214118725

申请日期：2012.05.21

申请公布日期：2015.04.14

申请人：

Rush University Medical Center

发明人：Pahan Kalipada

分类号：A61K48/00;C07H21/02;C07H21/04;A61K38/00;A61P25/28;A61K31/4178;A61K31/7088;C12N15/113

主分类号：A61K48/00

代理机构：

Brinks Gilson & Lione

代理人：Brinks Gilson & Lione

地址：Chicago IL US

摘要：Alzheimer's disease (AD) is the most common human neurodegenerative disease of the CNS resulting in progressive neuronal death and memory loss. Despite intense investigations, no effective therapy is available to stop its onset or halt its progression. It was discovered that antisense oligonucleotide against neutral sphingomyelinase and GW4869, a chemical inhibitor of neutral sphingomyelinase, inhibit activation of glial cells and protect neurons in AD cell culture and animal models. These results suggest the following new treatment options for AD patients: Antisense oligonucleotide against neutral sphingomyelinase and GW4869.

主权项：1. A method of treating a neurodegenerative disorder in a mammal in need thereof, the method comprising: administering a composition comprising GW4869 to the mammal to treat the neurodegenerative disorder.

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