SPIRO-OXINDOLE MDM2 ANTAGONISTS.

申请公布号：MX2013013167(A)

申请号：MX20130013167

申请日期：2012.05.11

申请公布日期：2014.07.09

申请人：

SANOFI

发明人：SHAOMENG WANG;WEI SUN;ANGELO AGUILAR;CARLOS GARCIA-ECHEVERRIA

分类号：C07D487/10;A61K31/407;A61P35/00;C07D413/12

主分类号：C07D487/10

摘要：<p>Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.</p>

PROCESS FOR PRODUCING 19-NORSTEROIDS COMPRISING CARBON CHAIN SUBSTITUTED IN 11BETA POSITION BY AMIDE OR CARBAMAGTE GROUP, AS WELL AS PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS AS ACTIVE INGREDIENT

PROCESS FOR PRODUCING QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS

PROCESS AND APPARATUS FOR MANUFACTURING EXTRUDED BULKY GRANULOUS PRODUCT

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HIP-JOINT PROSTHESIS STALK

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ANTI-FREEZE LIQUID UNIFRIGO 2001

MAGIC SPHERE

CONCEPTION FOR PRODUCING ENERGY

MANUFACTURING DEVOTIONAL AND OTHER OBJECTS OF PLASTIC

PRODUCING ACTIVE SUBSTANCE OF MEDICAMENT

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