TUMOR SELECTIVE CHEMOKINE MODULATION,申请号KR20147004613-传众专利搜索

TUMOR SELECTIVE CHEMOKINE MODULATION

申请公布号：KR20140071340(A)

申请号：KR20147004613

申请日期：2012.07.23

申请公布日期：2014.06.11

申请人：

KALINSKI PAWEL;MUTHUSWAMY RAVIKUMAR

发明人：KALINSKI PAWEL;MUTHUSWAMY RAVIKUMAR

分类号：A61K39/395;A61K31/44;A61K38/21;A61P35/00

主分类号：A61K39/395

摘要：Therapies effective for the treatment and prevention of cancer and other diseases are disclosed. These methods include the administration of therapeutically effective amounts of agents that increase the local production of effector cell-attracting chemokines within tumor lesions, with concomitant suppression of local production of undesirable chemokines that attract regulatory T(reg) cells. These methods include administering to the subject therapeutically effective amounts of a Toll-like receptor (TLR) agonist or other activator of NF-KB pathway in combination with a blocker of prostaglandin synthesis or a blocker of prostaglandin signaling, in combination with a type-1 interferon, or in combination with both a blocker of prostaglandin synthesis or signaling and with a type-1 interferon. Alternatively, the methods derived from the same paradigms, but aimed to treat or prevent autoimmune disease, chronic inflammatory disease, transplant rejection or GvR, include the combination of a Toll-like receptor (TLR) agonist in combination with a prostaglandin or other cAMP-activator.