Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof
申请公布号:US8664241(B2)
申请号:US201314019940
申请日期:2013.09.06
申请公布日期:2014.03.04
发明人:HOOD JOHN;WALLACE DAVID MARK;KUMAR KC SUNIL
分类号:A01N43/42;A61K31/44;C07D513/02;C07D515/02
主分类号:A01N43/42
摘要:Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
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