COHESIVE GELS FROM CROSS-LINKED HYALURONAN AND/OR HYLAN, THEIR PREPARATION AND USE,申请号CA20042550718-传众专利搜索

COHESIVE GELS FROM CROSS-LINKED HYALURONAN AND/OR HYLAN, THEIR PREPARATION AND USE

申请公布号：CA2550718(C)

申请号：CA20042550718

申请日期：2004.12.30

申请公布日期：2013.11.05

申请人：

GENZYME CORPORATION

发明人：LESHCHINER, ADELYA K.;KONOWICZ, PAUL A.;VASILYEVA, VALENTINA

分类号：C08B37/08;A61K9/00;A61K31/728;A61K47/36

主分类号：C08B37/08

摘要：Disclosed are highly resilient and cohesive gels formed by the cross-linking of hyaluronan or hylan, their salts or derivatives thereof, using divinyl sulfone (DVS) as the cross-linking agent. Also disclosed are viscoelastic fluids containing alkylsulfone groups covalently attached to the backbone of the polymer, formed by the mono-functionalization of the cross-linking monomer DVS with hyaluronan and/or hylan. Mechanical properties such as values of hardness and cohesiveness are specified by the rheological properties of the gels. Also disclosed are methods for the preparation of such products. They have use in many applications as injectable and/or implantable devices and as drug delivery systems.