ANTIBODY WITH IMMUNE EFFECTOR ACTIVITY AND THAT INTERNALIZES IN FOLATE RECEPTOR ALPHA-POSITIVE CELL

申请公布号：JP2012100675(A)

申请号：JP20110290406

申请日期：2011.12.29

申请公布日期：2012.05.31

申请人：

MORPHOTEK INC

发明人：GRASSO LUIGI;NICOLAIDES NICHOLAS C;SASS PHILIP M

分类号：C12N15/09;A61K39/395;A61K51/00;A61P35/00;C07K14/705;C07K16/28;C07K16/46;C12N5/10;C12N15/02;C12P21/08;G01N33/53

主分类号：C12N15/09

摘要：<P>PROBLEM TO BE SOLVED: To provide antibodies targeting folate receptor alpha (FRA) that overexpresses in a variety of carcinoma, and diagnostic and therapeutic agents for cancers. <P>SOLUTION: This invention relates to: the use of monoclonal and polyclonal antibodies that specifically bind to cells expressing FRA and have the ability in the alternative to become internalized by the cells and to induce an immune effector activity such as antibody-dependent cellular cytotoxicity; nucleotides encoding the antibodies; cells expressing the antibodies; and methods for detecting and treating cancer cells using the antibodies. <P>COPYRIGHT: (C)2012,JPO&INPIT

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