Novel method for down-regulation of amyloid,申请号EP20050021931-传众专利搜索

Novel method for down-regulation of amyloid

申请公布号：EP1632242(A3)

申请号：EP20050021931

申请日期：2001.02.19

申请公布日期：2011.08.31

申请人：

H. LUNDBECK A/S

发明人：BIRK, PETER;JENSEN, MARTIN ROLAND;NIELSEN, KLAUS GREGORIUS

分类号：A61K38/00;G01N33/53;A61K35/12;A61K35/66;A61K35/76;A61K38/16;A61K38/17;A61K38/18;A61K38/20;A61K39/00;A61K39/385;A61K39/39;A61K48/00;A61P25/28;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/02

主分类号：A61K38/00

摘要：<p>Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloidogenic proteins (proteins contributing to formation of amyloid) such as beta amyloid (Aβ). Immunization is preferably effected by administration of analogues of autologous amyloidogenic polypeptides, said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes while substantially preserving the majority of Aβ's B-cell epitopes. Also disclosed are nucleic acid vaccination against amyloidogenic polypeptides and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for identification of useful immunogenic analogues of the amyloidogenic proteins, methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.</p>