Compositions of Engineered Human Arginases and Methods for Treating Cancer,申请号US20090610685-传众专利搜索

Compositions of Engineered Human Arginases and Methods for Treating Cancer

申请公布号：US2010111925(A1)

申请号：US20090610685

申请日期：2009.11.02

申请公布日期：2010.05.06

申请人：

THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人：GEORGIOU GEORGE;STONE EVERETT

分类号：A61K38/46;A61P35/00;C07H21/00;C12N5/00;C12N9/78;C12N9/96;C12N15/63

主分类号：A61K38/46

摘要：Compositions and methods for the treatment of cancer are described, and, more preferably, to the treatment of cancers that do not express, or are otherwise deficient in, argininosuccinate synthetase, with enzymes that deplete L-Arginine in serum. In one embodiment, the present invention contemplates an arginase protein, such as a human Arginase I protein, comprising at least one amino acid substitution and a metal cofactor, said protein comprising an increased catalytic activity when compared with a native human Arginase I.