LENTIVIRALE VEKTOREN FÜR DIE HERSTELLUNG VON IMMUNOTHERAPEUTISCHEN ZUSAMMENSETZUNGEN,申请号AT19990402492T-传众专利搜索

LENTIVIRALE VEKTOREN FÜR DIE HERSTELLUNG VON IMMUNOTHERAPEUTISCHEN ZUSAMMENSETZUNGEN

申请公布号：AT449858(T)

申请号：AT19990402492T

申请日期：1999.10.11

申请公布日期：2009.12.15

申请人：

INSTITUT PASTEUR;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人：CHARNEAU, PIERRE;FIRAT, HUESEYIN;ZENNOU, VERONIQUE

分类号：C12N15/09;C12N15/86;A61K35/76;A61K39/00;A61K39/02;A61K39/04;A61K48/00;A61P31/00;A61P31/12;A61P35/00;C07K14/35;C12N5/10;C12N7/00;C12N7/01;C12N15/867

主分类号：C12N15/09

摘要：The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or sequence of interest) and regulatory signals of retrotranscription, expression and encapsidation of retroviral or retroviral-like origin, wherein the composition is capable of inducing or of stimulating a cell-mediated response for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response, against one or several epitopes encoded by the transgene sequence present in the vector.