Nitric Oxide Enhancing Glutamic Acid Compounds, Compositions and Methods of Use,申请号US20060096328-传众专利搜索

Nitric Oxide Enhancing Glutamic Acid Compounds, Compositions and Methods of Use

申请公布号：US2009053328(A1)

申请号：US20060096328

申请日期：2006.12.19

申请公布日期：2009.02.26

申请人：

NITROMED, INC.

发明人：GARVEY DAVID S.

分类号：A61K33/00;A61K31/4245;A61K31/5377;C07D271/04;C07D413/12

主分类号：A61K33/00

摘要：The invention provides novel compositions and kits comprising at least one nitric oxide enhancing glutamic acid compound, or a pharmaceutically acceptable salt thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (l) treating peripheral vascular diseases; (m) treating portal hypertension (n) treating diseases resulting from elevated levels of gamma-glutamyl transpeptidase and (O) the targeted delivery of compounds and nitric oxide to organs, cells or tissues containing the enzyme gamma-glutamyl transpeptidase. The nitric oxide enhancing glutamic acid compounds comprise at least one heterocyclic nitric oxide donor group and/or at least one nitroxide group.