NOVEL PHOTOSENSITIZER BASED ON POLYMER DERIVATIVES-PHOTOSENSITIZER CONJUGATES FOR PHOTODYNAMIC THERAPY,申请号WO2008KR02283-传众专利搜索

NOVEL PHOTOSENSITIZER BASED ON POLYMER DERIVATIVES-PHOTOSENSITIZER CONJUGATES FOR PHOTODYNAMIC THERAPY

申请公布号：WO2008130181(A1)

申请号：WO2008KR02283

申请日期：2008.04.23

申请公布日期：2008.10.30

申请人：

KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY;KWON, ICK-CHAN;CHOI, KUI-WON;KIM, KWANG-MEYUNG;YOUN, IN-CHAN;KIM, JONG-HO;PARK, KYEONG-SOON

发明人：KWON, ICK-CHAN;CHOI, KUI-WON;KIM, KWANG-MEYUNG;YOUN, IN-CHAN;KIM, JONG-HO;PARK, KYEONG-SOON

分类号：A61K49/12

主分类号：A61K49/12

摘要：Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizer for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.