A NON-DESTRUCTIVE METHOD TO QUANTIFY AND ISOLATE ANTIGEN-SPECIFIC B CELLS AND USES THEREOF,申请号CA20082719522-传众专利搜索

A NON-DESTRUCTIVE METHOD TO QUANTIFY AND ISOLATE ANTIGEN-SPECIFIC B CELLS AND USES THEREOF

申请公布号：CA2719522(A1)

申请号：CA20082719522

申请日期：2008.03.26

申请公布日期：2008.10.02

申请人：

UNIVERSITY OF MARYLAND, BALTIMORE

发明人：FLINKO, ROBIN;LEWIS, GEORGE K.;DEVICO, ANTHONY L.

分类号：A61K39/00;C07K16/00;C12N5/00;G01N33/53;G01N33/566

主分类号：A61K39/00

摘要：The present invention relates to antigen-Ig Ab fusion molecules and methods of using same, wherein antigen-Ig Ab fusion molecules include an antigen fused to an immunoglobulin molecule, fragment or variant thereof and wherein the fusing of the immunoglobulin molecule to the antigen does not alter the specificity or tertiary structure of important epitopes of the antigen. This method allows the direct quantification and isolation of antigen-specific B cells by flow cytometry in essentially any species.