GENE POLYMORPHISMS AS PREDICTORS OF TUMOR PROGRESSION AND THEIR USE IN CANCER THERAPY

申请公布号：CA2675354(A1)

申请号：CA20082675354

申请日期：2008.01.17

申请公布日期：2008.07.24

申请人：

UNIVERSITY OF SOUTHERN CALIFORNIA

发明人：ZHANG, WU;LENZ, HEINZ-JOSEF

分类号：C12Q1/68

主分类号：C12Q1/68

摘要：The invention provides compositions and methods for determining the likel ihood of successful treatment with a pyrimidine based antimetabolite chemoth erapy drug and a platinum based chemotherapy drug, such as 5-FU/oxaliplatin. The methods comprise determining the genomic polymorphism present in a pred etermined region of a gene of interest and correlating the polymorphism to t he predictive response. Patients identified as responsive are then treated w ith the appropriate therapy.

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