UPREGULATING BDNF LEVELS TO MITIGATE MENTAL RETARDATION,申请号US20070868336-传众专利搜索

UPREGULATING BDNF LEVELS TO MITIGATE MENTAL RETARDATION

申请公布号：US2008139472(A1)

申请号：US20070868336

申请日期：2007.10.05

申请公布日期：2008.06.12

申请人：

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人：LAUTERBORN JULIE;LYNCH GARY;GALL CHRISTINE;REX CHRISTOPHER

分类号：A61K38/17;A61K31/135;A61K31/138;A61K31/145;A61K31/197;A61K31/405;A61K31/454;A61K31/465;A61K31/498;A61K31/536;A61K31/5365;A61K31/549;A61K31/565;A61P43/00

主分类号：A61K38/17

摘要：This invention provides methods of preserving, improving, or restoring cognitive function in mammal having one or more mutations in the FMR1 gene (e.g. at risk for or having fragile x syndrome), where the methods involve the brain derived neurotrophic factor (BDNF) level or activity in the brain of said mammal. In certain embodiments the methods involve administering one or more AMPA potentiators (e.g., ampakines) to the mammal in an amount sufficient to increase BDNF levels in the brain of the mammal.