2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF ß-SECRETASE (BACE),申请号WO2007US61704-传众专利搜索

2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF ß-SECRETASE (BACE)

申请公布号：WO2007092854(A2)

申请号：WO2007US61704

申请日期：2007.02.06

申请公布日期：2007.08.16

申请人：

JANSSEN PHARMACEUTICA N.V.;BAXTER, ELLEN;REITZ, ALLEN B.;HUANG, YIFANG;CREIGHTON, CHRISTOPHER JOHN;MAHAROOF, UMAR SAIBU MOHOMED;REYNOLDS, CHARLES H.;LUO, CHI;TOUNGE, BRETT A.;ROSS, TINA MORGAN;LU, TIANBAO

发明人：BAXTER, ELLEN;REITZ, ALLEN B.;HUANG, YIFANG;CREIGHTON, CHRISTOPHER JOHN;MAHAROOF, UMAR SAIBU MOHOMED;REYNOLDS, CHARLES H.;LUO, CHI;TOUNGE, BRETT A.;ROSS, TINA MORGAN;LU, TIANBAO

摘要：The present invention is directed to 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of b-secretase, also known as b-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.