METHODS OF SYNTHESIZING 6-ALKYLAMINOQUINOLINE DERIVATIVES,申请号CA20062608589-传众专利搜索

METHODS OF SYNTHESIZING 6-ALKYLAMINOQUINOLINE DERIVATIVES

申请公布号：CA2608589(A1)

申请号：CA20062608589

申请日期：2006.04.26

申请公布日期：2006.11.30

申请人：

WYETH

发明人：RABINDRAN, SRIDHAR KRISHNA;MCGINNIS, JOHN PATRICK, II;WISSNER, ALLAN;DISCAFANI-MARRO, CAROYLN;CHEW, WARREN;WANG, YOUCHU

分类号：C07D215/44;C07C271/22;C07D403/12

主分类号：C07D215/44

摘要：The present invention is directed to a method of synthizing compounds of formula (I): wherein X, Z, V, R1, R3, R4, G2, n, x, y, and z are defined herein. This invention also includes a method of preparing acid compounds of formula (VII): wherein R is H, and R4, x, y, and z are as defined herein and PG is a protecting group. This invention is also directed to (E)N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(methylamino)-2-butenamide, compositions containing it and methods of using the to treat cancer.