Method of producing 1-hydroxy-1,1-diphosphonic acid compounds,申请号US20030471828-传众专利搜索

Method of producing 1-hydroxy-1,1-diphosphonic acid compounds

申请公布号：US7078393(B2)

申请号：US20030471828

申请日期：2003.09.15

申请公布日期：2006.07.18

申请人：

EUCRO EUROPEAN CONTRACT RESEARCH GMBH & CO. KG

发明人：BLUM HELMUT;GREB WOLFGANG;PUSTOVIT YURII;ROESCHENTHALER GERD-VOLKER

分类号：A61K31/66;C07F7/18;C07F9/28;C07F9/38;C07F9/40

主分类号：A61K31/66

摘要：In a method for preparing 1-hydroxy-1,1-diphosphonic acid compounds of the general formula I and/or of their pharmacologically compatible salts a compound of the formula II is reacted with a compound P(OSiR53)3-pR6p and the reaction product is hydrolyzed.