PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS,申请号WO2004US43169-传众专利搜索

PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS

申请公布号：WO2005066176(A1)

申请号：WO2004US43169

申请日期：2004.12.23

申请公布日期：2005.07.21

申请人：

BRISTOL-MYERS SQUIBB COMPANY;FINK, BRIAN, E.;GAVAI, ASHVINIKUMAR, V.;VITE, GREGORY, D.;CHEN, PING;MASTALERZ, HAROLD;NORRIS, DEREK, J.;TOKARSKI, JOHN, S.;ZHAO, YUFEN;HAN, WEN-CHING

发明人：FINK, BRIAN, E.;GAVAI, ASHVINIKUMAR, V.;VITE, GREGORY, D.;CHEN, PING;MASTALERZ, HAROLD;NORRIS, DEREK, J.;TOKARSKI, JOHN, S.;ZHAO, YUFEN;HAN, WEN-CHING

分类号：A61K31/53;C07D487/04;C07D519/00;(IPC1-7):C07D487/04;A61P35/00

主分类号：A61K31/53

摘要：<p>The present invention provides compounds of formula (I); and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.</p>