Apparatus and method for detecting and locating rare cells,申请号US20030616366-传众专利搜索

Apparatus and method for detecting and locating rare cells

申请公布号：US2004071332(A1)

申请号：US20030616366

申请日期：2003.07.09

申请公布日期：2004.04.15

申请人：

XEROX CORPORATION

发明人：BRUCE RICHARD H.;CURRY DOUGLAS N.;KRIVACIC ROBERT T.;HSIEH HUANGPIN B.

分类号：G01N21/64;G01N15/00;G01N15/14;G01N21/27;G01N33/483;(IPC1-7):G06K9/00

主分类号：G01N21/64

摘要：In accordance with one aspect of the present application, an imager and method for detecting and locating rare cells in a sample is disclosed. An imager stage supports the sample. A fiber optic bundle has a proximate bundle end of first fiber ends arranged to define an input aperture viewing the sample on the translation stage. The fiber optic bundle further has a distal bundle end of second fiber ends arranged to define an output aperture shaped differently from the input aperture and disposed away from the imager stage. A scanning radiation source is arranged in fixed relative position to the input aperture. The scanning radiation source scans a radiation beam on the sample within a viewing area of the input aperture. The radiation beam interacts with the sample to produce a light signal that is reflected, scattered, transmitted, re-emitted, or otherwise collected and received by the input aperture and transmitted via the fiber optic bundle to the output aperture. The scanning radiation source rasters the radiation beam over a selected area of the sample. A photodetector is arranged to detect the light signal at the distal bundle end, and a processor processes the detected light signals.