Method and device for photothermal imaging tiny metal particles immersed in a given medium,申请号US20030386937-传众专利搜索

Method and device for photothermal imaging tiny metal particles immersed in a given medium

申请公布号：US2004052292(A1)

申请号：US20030386937

申请日期：2003.03.13

申请公布日期：2004.03.18

申请人：

LOUNIS BRAHIM;BOYER DAVID STEPHANE CHRISTOPHE;TAMARAT PHILIPPE;MAALI ABDELHAMID;ORRIT MICHEL ALAIN GASTON JULIEN

发明人：LOUNIS BRAHIM;BOYER DAVID STEPHANE CHRISTOPHE;TAMARAT PHILIPPE;MAALI ABDELHAMID;ORRIT MICHEL ALAIN GASTON JULIEN

分类号：G01N15/10;G01N15/14;(IPC1-7):G01N25/20

主分类号：G01N15/10

摘要：A method and device for photothermal imaging tiny metal particles which are immersed in a given medium like a living cell. The given medium and immersed tiny metal particles are illuminated through separate phase reference laser beam and sensitive probe laser beam, with the sensitive probe laser beam undergoing through impingement on the given medium slight phase changes induced by photothermal effect due to a local heating thanks to a heating laser beam, in the absence of any substantial phase changes to the phase reference laser beam. Illuminating is performed by focusing the separate phase reference laser beam. The induced slight phase changes on the sensitive probe laser beam with reference to the phase reference laser beam are detected through differential phase interference contrast phenomenon so as to allow each of the tiny metal particles in the given medium to be imaged as an optical label.