SEROLOGICAL METHOD FOR DETECTING INTESTINAL MICROVILLI ATROPHY IN PATIENTS SUFFERING FROM COELIAC DISEASE,申请号WO2003IT00080-传众专利搜索

SEROLOGICAL METHOD FOR DETECTING INTESTINAL MICROVILLI ATROPHY IN PATIENTS SUFFERING FROM COELIAC DISEASE

申请公布号：WO03079012(A2)

申请号：WO2003IT00080

申请日期：2003.02.14

申请公布日期：2003.09.25

申请人：

DIPARTIMENTO DI SCIENZE BIOMEDICHE E BIOTECNOLOGIE;DE VIRGILIIS, STEFANO;CLEMENTE, MARIA, GRAZIA

发明人：DE VIRGILIIS, STEFANO;CLEMENTE, MARIA, GRAZIA

分类号：G01N33/564

主分类号：G01N33/564

摘要：Method for detecting intestinal microvilli atrophy in a patient suffering from coeliac disease including immunological detection of anti F-actin autoantibodies in a biological fluid from the patient consisting of the following steps: a) preparation of a normal epithelial cell culture from small bowel of experimental animal; b) incubation with the patient fluid; c) detection of the binding of anti F-actin autoantibodies to the cells. Further said method can include, following step a) the incubation with a substance able to induce the polymerisation of globular actin to filaments.