Recombinant p53 adenovirus methods and compositions,申请号US20020170240-传众专利搜索

Recombinant p53 adenovirus methods and compositions

申请公布号：US2003012770(A1)

申请号：US20020170240

申请日期：2002.06.11

申请公布日期：2003.01.16

申请人：

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人：ZHANG WEI-WEI;ROTH JACK A.

分类号：C12N15/09;A61K9/127;A61K35/76;A61K38/00;A61K38/17;A61K38/22;A61K48/00;A61P35/00;A61P35/04;A61P43/00;C07K14/47;C07K14/82;C12N5/10;C12N7/00;C12N15/11;C12N15/12;C12N15/33;C12N15/86;C12N15/861;(IPC1-7):A61K48/00

主分类号：C12N15/09

摘要：Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct observation of a cytopathic effect (CPE) in the transfected cells. Also disclosed are compositions and methods involving novel p53 adenovirus constructs, including methods for restoring p53 function and tumor suppression in cells and animals having abnormal p53.