SUSTAINED RELEASE RANOLAZINE FORMULATIONS

申请公布号：SI1109558(T1)

申请号：SI19990030078T

申请日期：1999.09.09

申请公布日期：2002.10.31

申请人：

CV THERAPEUTICS, INC.;SYNTEX (U.S.A.) LLC

发明人：WOLFF ANDREW A.;BAKER FIONA;LANGRIDGE JOHN

分类号：A61K9/20;A01N43/58;A01N43/60;A61K9/22;A61K9/28;A61K9/52;A61K31/495;A61K31/50;A61K47/32;A61K47/34;A61K47/38;A61P9/00;A61P9/06;A61P9/10;(IPC1-7):A61K31/495

主分类号：A61K9/20

摘要：<p>A sustained release ranolazine formulation contains an intimate mixture of ranolazine and a partially neutralized pH-dependent binder to form a film that is mostly insoluble in aqueous media below pH 4.5 and soluble in aqueous media above pH 4.5. The formulation is suitable for twice daily administration of ranolazine and is useful for controlling the rate of dissolution of ranolazine, and to maintain human plasma ranolazine levels at between 850 and 4000 ng base/mL.</p>

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