New pharmaceutical active compounds,申请号US20010865231-传众专利搜索

New pharmaceutical active compounds

申请公布号：US2001025043(A1)

申请号：US20010865231

申请日期：2001.05.25

申请公布日期：2001.09.27

申请人：

ASTRA AKTIEBOLAG, A SWEDEN CORPORATION

发明人：BERGSTRAND HAKAN;KARABELAS KOSTAS;SJO PETER

分类号：C07D403/04;C07D405/14;C07D471/04;C07D475/00;C07D475/02;C07H19/04;(IPC1-7):A61K31/498

主分类号：C07D403/04

摘要：The present invention provides optionally substituted and/or annulated compounds of formula (I) wherein X, Y, Z and A is each independently carbon or nitrogen, and at least two of X, Y, Z and A are carbon; and pharmaceutically acceptable salts thereof with the proviso that: 3-(1H-Indol-3-yl)-1H-quinoxalin-2-one, 3-(2-Methyl-1H-indol-3-yl)-1H-quinoxalin-2-one, and 3-(1,2-Diphenyl-1H-indol-3-yl)-1H-quinoxalin-2-one are excluded from compounds of formula (I). The invention includes the use of compounds of formula (I) in medical therapy, particularly in the therapy of conditions requiring inhibition of protein kinase C.