THERAPEUTIC CALCIUM PHOSPHATE PARTICLES AND METHODS OF MANUFACTURE AND USE,申请号CA20002361421-传众专利搜索

THERAPEUTIC CALCIUM PHOSPHATE PARTICLES AND METHODS OF MANUFACTURE AND USE

申请公布号：CA2361421(A1)

申请号：CA20002361421

申请日期：2000.02.03

申请公布日期：2000.08.10

申请人：

BIOSANTE PHARMACEUTICALS, INC.

发明人：MORCOL, TULIN;HE, QING;BELL, STEVE J. D.

分类号：A61K9/00;A61K9/12;A61K9/16;A61K9/51;A61K38/28;A61K39/00;A61K39/145;A61K39/245;A61K39/39;C01B;C01B25/32;(IPC1-7):C01B25/32

主分类号：A61K9/00

摘要：<p>Novel calcium phosphate core particles, methods of making them, and methods of using them as vaccine adjuvants, as cores, as carriers of biologically activ e material, and as controlled release matrices for biologically active materia l are disclosed. The core particles may have a surface modifying agent and/or biologically active material, such as antigenic material or natural immunoenhancing factor, polynucleotide material, or therapeutic proteins or peptides, partially coating the particle or impregnated therein. The core particles have a diameter between about 300 nm and about 4000 nm, more particularly between about 300 nm and about 2000 nm, and even more particularly between about 300 nm and about 1000 nm, are substantially spherical in shape, and have a substantially smooth surface.</p>