INCLUSION COMPLEXES OF ARYL-HETEROCYCLIC SALTS

申请公布号：YU17297(A)

申请号：YU19970000172

申请日期：1997.05.06

申请公布日期：1999.12.27

申请人：

PFIZER INC.

发明人：JOHNSON, KEVIN CHARLES;KIM, YESOOK;SHANKER, RAVI MYSORE

分类号：C07D417/14;A61K31/496;A61K31/724;A61K47/48;C07D237/00

主分类号：C07D417/14

摘要：<p>Opisane su kompozicije supstanci koje obuhvataju farmaceutski prihvatljivu so aril-heterociklicnog jedinjenja, kao sto je ziprasidon u ciklodekstrinu. Pozeljni ciklodekstrini su SBECD i HPBCD. Kompozicija moze obuhvatiti suvu smesu, suvi inkluzioni kompleks ili vodeni rastvor. Pozeljno je da so/ciklodekstrin inkluzioni kompleks obezbedi kolicinu ziprasidona od najmanje 2,5 mgA/ml kada je kompleks rastvoren u vodi kao 40 % t/z. Pozeljne su razlicite ziprasidonove soli ukljucujuci mezilate, ezilate, bezilate, tartarate, napsilate i tozilate.</p>

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