HETEROCYCLICALLY-SUBSTITUTED 1-INDOLE CARBOXAMIDES AS CYCLO-OXYGENASE-2 INHIBITORS,申请号EP1996004293-传众专利搜索

HETEROCYCLICALLY-SUBSTITUTED 1-INDOLE CARBOXAMIDES AS CYCLO-OXYGENASE-2 INHIBITORS

申请公布号：WO1997013767(A1)

申请号：EP1996004293

申请日期：1996.10.02

申请公布日期：1997.04.17

摘要：<p>The invention concerns novel heterocyclically-substituted 1-indole carboxamides of general formula (I) in which: A means a mono or polycyclic 5 to 12-member heteroaryl group with 1 to 4 heteroatoms such as O, S or N which can optionally be substituted by lower alkyl, perfluoro lower alkyl, lower alkoxy, halogen or nitro; B means a mono or polycyclic 5 to 12-member aryl or heteroaryl group with 1 to 4 heteroatoms such as O, S or N which can optionally be substituted by lower alkyl, perfluoro lower alkyl, lower alkoxy, lower alkylthio, acetyl, lower alkoxy carbonyl, methylsulphonyl, halogen, cyano or nitro; X means hydrogen or a mono or polycyclic 5 to 12-member aryl or heteroaryl group with 1 to 4 heteroatoms such as O, S or N, which can optionally be substituted by lower alkyl, perfluoro lower alkyl, lower alkoxy, halogen or nitro; and R means hydrogen, (a), in which R1 means lower alkyl and R2 means lower alkyl, aryl or -OR3 with R3 meaning lower alkyl, cycloalkyl with 4 to 8 carbon atoms or aryl. The invention further concerns their pharmaceutically acceptable salts, a process for preparing these substances and their use.</p>