Human Monoclonal Antibodies Specific to Cell Cycle Independent Glioma Surface Antigen

申请公布号：CA2192079(A1)

申请号：CA19952192079

申请日期：1995.06.16

申请公布日期：1995.12.28

申请人：

DAN, MICHAEL D.

发明人：DAN, MICHAEL D.

分类号：C12N15/09;A61K38/00;C07K7/06;C07K14/47;C07K16/30;C07K16/46;C12N15/13;C12P21/08;(IPC1-7):C12N15/13;C07K14/705;A61K47/48

主分类号：C12N15/09

摘要：The variable chains of two human monoclonal antibodies (HMAbs) of the IgM isotype are characterized by elucidation of cDNAs encoding those chains. The HMAbs are specific against cell cycle independent, glioma-associated antigen , and the antibodies do not recognize cultured normal human astrocytes. Immunoconjugates based on the sequences identified should target both proliferating and non-proliferating glioma cells in vivo, thus providing a valuable adjunctive therapy in the treatment of these tumors.

AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS

HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS

SENSING ELEMENT

OUTDOOR ADVERTISEMENT CARRIER

METHOD OF AND APPARATUS FOR MEASURING ENERGY CHARACTERISTICS OF EXPLOSIVES

SYSTEM FOR RECTIFYING AN OUT-OF-PLUMB BUILDING STRUCTURE, IN PARTICULAR A HOIST TOWER

KNITTED FABRIC IN PARTICULAR THAT FOR LOOSE WARM UNDEWEAR ITEMS AND LOOSE CLOTHING ITEMS

SMOKING AND STEAMING CHAMBER

AIR GRATE

SECTION

SPOON-NET

SEED TREATMENT COMPOSITION

Fremgangsmåte og analysesett for analyse av homocystein

Anordning ved en båt med en kjöl

Innretning for telling og klassifisering av lastsykluser for b¶rende konstruksjoner med vekslende laststörrelser

Sville for skinner i et jernbanespor som utnytter den interne friksjonen iet underliggende pukklag

Kretsbeskyttelsesanordning

OLIGOMERIZACION CATALITICA.

PROCEDIMIENTO PARA LA PREPARACION DE COMPOSICIONES DE VITAMINA B12 DE ALTA CONCENTRACION.

MATERIA PROTEICA DE DIGESTION RELENTIZADA Y SU UTILIZACION.