Process for preparation of azolylmethylcycloalkanol derivatives,申请号US19940337275-传众专利搜索

Process for preparation of azolylmethylcycloalkanol derivatives

申请公布号：US5466816(A)

申请号：US19940337275

申请日期：1994.11.10

申请公布日期：1995.11.14

申请人：

KUREHA CHEMICAL INDUSTRY CO., LTD.

发明人：YOSHIDA, EYJI;KUSANO, NOBUYUKI;KUMAZAWA, SATORU

分类号：A01N43/50;A01N43/653;C07D233/60;C07D249/08;C07D521/00;(IPC1-7):C07D249/08

主分类号：A01N43/50

摘要：A process for preparing a derivative of azolylmethylcycloalkanol of the following formula (I) comprising, providing a solid-liquid two-phase mixture of a cycloalkanone derivative of formula (II), an azole compound of formula (III), a metal oxide of formula (IV), and an organic solvent, and adding a sulfonium compound of formula (V) to said solid-liquid two-phase mixture under heating while stirring, <IMAGE> (II) + <IMAGE> (III) + M2O (IV) <IMAGE> (V) <IMAGE> (I) wherein R1 and R2 individually represent a hydrogen atom or an alkyl group; X is a halogen atom, an alkyl group, a haloalkyl group, a phenyl group, a cyano group, or a nitro group; m is an integer of 0 to 5 (when m is 2 or larger, Xs may be either the same or different); n is an integer of 0 to 2; A represents a nitrogen atom or a group CH; M1 represents an alkali metal atom or an alkaline earth metal atom; M2 represents an alkaline earth metal atom, a zinc atom, or two alkali metal atoms; Y represents a halogen atom or a C1-C4 alkoxysulfonyloxy group; and p denotes an integer of 0 or 1.