PROFEN RESOLUTION,申请号CA19922128525-传众专利搜索

PROFEN RESOLUTION

申请公布号：CA2128525(A1)

申请号：CA19922128525

申请日期：1992.12.08

申请公布日期：1993.07.22

申请人：

ETHYL CORP

发明人：MANIMARAN THANIKAVELU;POTTER ALICIA A

分类号：C07B57/00;C07C51/487;C07C57/30;C07C67/48;(IPC1-7):C07C53/132

主分类号：C07B57/00

摘要：2128525 9314056 PCTABS00024 A process is disclosed that is useful for separating the enantiomers of a racemic mixture of an aliphatic carboxylic acid having formula (I), where R1 is hydrogen or alkyl, R2, R3 and R4 are independently different and are hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, heteroaryl, substituted heteroaryl, haloalkyl, alkoxyalkyl, alkylthioalkyl, phenylalkyl, substituted phenylalkyl, heteroalkylalkyl, substituted heteroalkylalkyl or cycloalkylalkyl. The process comprises forming a conglomerate salt by reacting the racemic mixture with a base, the conglomerate salt being a mixture of the enantiomeric salts and having the following properties: i) the infrared spectrum of each of the enantiomeric salts, individually, and of the racemate salt are superposable; ii) the melting point of each of the enantiomeric salts, individually, is greater than the melting point of the racemate salt; and iii) the solubility of each of the enantiomeric salts, individually, is less than the solubility of the racemate salt in the same solvent. The enantiomeric salts are readily separable from the racemic mixture.