3,4-DEHYDROPIPERIDINE DERIVATIVES,申请号ZA19920005184-传众专利搜索

3,4-DEHYDROPIPERIDINE DERIVATIVES

申请公布号：ZA9205184(B)

申请号：ZA19920005184

申请日期：1992.07.10

申请公布日期：1993.04.28

申请人：

DUPHAR INTERNATIONAL RESEARCH B.V.

发明人：ANTONIUS HULKENBERG;KARIN JULIETTE VAN CHARLDORP;ROLF VAN HES;INEKE VAN WIJNGAARDEN

分类号：A61K31/435;A61K31/44;A61P25/04;C07D211/70;C07D333/52;C07D409/04

主分类号：A61K31/435

摘要：The invention relates to a group of new 3,4-dehydropiperidine derivatives of the formula <CHEM> wherein R<5> is a hydrogen atom or an alkyl group having 1-3 carbon atoms; Y is a group of the general formula 2 <CHEM> wherein R<6> is a group of the formula -(CH<6>)n-C(=X)-NR<7>R<8>, -(CH<6>)n-SO<6>-NR<7>R<8>, -(CH<6>)n-NR psi -C(=X)-R1/4 or -(CH<6>)n-NR psi -SO<6>-R1/4 , wherein R<7>, R<8> and R psi independent of each other represent hydrogen or alkyl (1-3C), R1/4 is alkyl (1-3C), X represents O or S; n is 0-4, and R is hydrogen or alkyl (1-3C). These compounds have interesting serotonin-1-like (partial) agonistic activity and can be used for the treatment of migraine.