METHODS FOR LABELLING OLIGONUCLEOTIDES

申请公布号：WO1992010505(A1)

申请号：US1991009247

申请日期：1991.12.11

申请公布日期：1992.06.25

摘要：<p>A method for labelling the 5' end of a nucleotide synthesized on a solid support involves reacting the free 5' hydroxyl with a reactant member selected to activate the 5' terminus; reacting the activated 5' terminus with a marker molecule containing a nucleophilic group; and cleaving the labelled nucleotide from the solid phase. The invention also relates to nucleotides labelled at their 5' end by the above process, wherein the nucleophilic group of the marker moiety is covalently attached directly to the 5' carbon; and to nucleotide intermediates having activated 5' termini.</p>

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